Regent Seven Seas Cruises cruise deals to Panama Canal/C. America

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22 Matching Cruises

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was $20,798

Up to 64% off
11 Night Crescent Beaches & Colorful Towns

Seven Seas Prestige - New Ship!
Departing from: Panama City, Panama
Ports of Call

Sailing Dates

Bonus Offers
Ports of Call:
Panama Canal Full Transit
Puerto Limon, Costa Rica
Roatan (Isla Roatan), Bay Islands, Honduras
Harvest Caye, Belize
Santo Tomas De Castilla, Guatemala
Cozumel, Mexico
George Town, Grand Cayman
Falmouth, Jamaica
Miami, Florida
Sailing Dates:
February 22, 2027
interior from

Not Available

oceanview from

Not Available

balcony from

Not Available

suite from

$7,399

$673pernight
All the Cruise Line Offers & More:

Enjoy an Additional 5% SavingsFor a limited-time, you can enjoy an additional 5% savings off of your cruise fare in exchange for a non-refundable booking deposit. Your normal deposit payment schedule will still apply. If you choose to cancel the booking, your deposit amount will be non-refundable, but the remainder of the fare paid will follow Regent Seven Seas Cruises normal penalties and cancellation policy. This non-refundable deposit offer applies to any voyage of 60 nights or less, booked 180 days or more prior to the date of embarkation. This offer is for new bookings only and may not be combinable with all fares but is combinable with most promotions shown. Offer applies to all suite categories except for the Regent Suite. Availability of this offer is subject to availability and Regent Seven Seas Cruises reserves the right to remove sailings at any time without notice. Call today for more information. Hurry - this offer ends soon.

Unlimited Shore Excursions, Drinks, more
Suite from$7,399
($673pernight)

View Itinerary View Itinerary Speak to an Expert
was $22,198

Up to 64% off
12 Night Bon Bin Aruba

Seven Seas Prestige - New Ship!
Departing from: Panama City, Panama
Ports of Call

Sailing Dates
Ports of Call:
Panama Canal Full Transit
Cartagena, Colombia
Oranjestad, Aruba
Willemstad, Curacao
St. George's, Grenada
Roseau, Dominica
Charlotte Amalie, St. Thomas, U.S.V.I.
Miami, Florida
Sailing Dates:
March 14, 2028
interior from

Not Available

oceanview from

Not Available

balcony from

Not Available

suite from

$8,099

$675pernight

Suite from$8,099
($675pernight)

View Itinerary View Itinerary Speak to an Expert

Get exclusive bonus offers

Our bonus offers vary by selected cruise but are designed to give you the best value at sea.

was $22,598

Up to 63% off
12 Night Flavors of Cartagena

Seven Seas Prestige - New Ship!
Departing from: Miami, Florida
Ports of Call

Sailing Dates
Ports of Call:
Key West, Florida
George Town, Grand Cayman
Falmouth, Jamaica
Cabo Rojo, Dominican Republic
Cartagena, Colombia
Puerto Limon, Costa Rica
Panama Canal Full Transit
Panama City, Panama
Sailing Dates:
March 02, 2028
interior from

Not Available

oceanview from

Not Available

balcony from

Not Available

suite from

$8,299

$692pernight

Suite from$8,299
($692pernight)

View Itinerary View Itinerary Speak to an Expert
was $23,998

Up to 65% off
14 Night Carnival of Caribbean Colors

Seven Seas Grandeur

4.3 rating out of 5 (10 reviews)
Departing from: Panama City, Panama
Ports of Call

Sailing Dates

Bonus Offers
Ports of Call:
Panama Canal Full Transit
Cartagena, Colombia
Santa Marta, Colombia
Oranjestad, Aruba
Willemstad, Curacao
Kralendijk, Bonaire
St. George's, Grenada
Castries, St. Lucia
Gustavia, St. Barts
Tortola, British Virgin Islands
Miami, Florida
Sailing Dates:
March 31, 2027
interior from

Not Available

oceanview from

Not Available

balcony from

Not Available

suite from

$8,499

$607pernight
All the Cruise Line Offers & More:

Exclusive: Up to an Extra $2,000 savings
Call to book select 2027 Regent Seven Seas voyages and save an extra $2,000. Savings is based upon length of voyage as well as suite category booked. On voyages of 14-nights or less, Deluxe and Superior Suites save up to $300 per suite, Concierge Suites save up to $400 per suite, and Penthouse Suites and above save up to $550 per suite. On 15 to 29-nights, Deluxe and Superior save up to $500 per suite, Concierge save up to $650 per suite, and Penthouse and above save up to $800 per suite. On 30-nights or longer, Deluxe and Superior save up to $1,000 per suite, Concierge save up to $1,500 per suite, and Penthouse Suites and above save up to $2,000 per suite. Solo guests will receive half of these amounts. New bookings only. May not be combinable with all fares or promotions shown. Call for details before this offer ends at 11:59 PM EST on 08/31/2025.

Enjoy an Additional 5% SavingsFor a limited-time, you can enjoy an additional 5% savings off of your cruise fare in exchange for a non-refundable booking deposit. Your normal deposit payment schedule will still apply. If you choose to cancel the booking, your deposit amount will be non-refundable, but the remainder of the fare paid will follow Regent Seven Seas Cruises normal penalties and cancellation policy. This non-refundable deposit offer applies to any voyage of 60 nights or less, booked 180 days or more prior to the date of embarkation. This offer is for new bookings only and may not be combinable with all fares but is combinable with most promotions shown. Offer applies to all suite categories except for the Regent Suite. Availability of this offer is subject to availability and Regent Seven Seas Cruises reserves the right to remove sailings at any time without notice. Call today for more information. Hurry - this offer ends soon.

Reduced Business-Class AirRegent Seven Seas Cruises is pleased to offer an incomparable inclusion that elevates their promise to deliver the most inclusive luxury experience: Reduced Business Class Air for all guests, for all suite categories on all Intercontinental flights. Arrive to your destination in complete comfort and style with Regent's Air-Inclusive Reduced Business Class Air program, including ground transfers between airport and ship, available from over 2 dozen popular US Gateways. Business-Class Air is subject to availability and may not be available on all sailings. All airline fees, surcharges and government fees, airline-imposed personal charges such as baggage fees may apply. Hurry - this offer will fly away soon. *35143

Unlimited Shore Excursions, Drinks, more

and more!
Suite from$8,499
($607pernight)

4.3 rating out of 5 (10 reviews)

View Itinerary View Itinerary Speak to an Expert
was $24,998

Up to 62% off
16 Night Southern Caribbean Beauty

Seven Seas Splendor

4.4 rating out of 5 (42 reviews)
Departing from: Miami, Florida
Ports of Call

Sailing Dates

Bonus Offers
Ports of Call:
Cozumel, Mexico
Costa Maya (Mahahual), Mexico
Harvest Caye, Belize
Roatan (Isla Roatan), Bay Islands, Honduras
Puerto Limon, Costa Rica
Panama Canal (Partial Transit)
Colon, Panama
Cartagena, Colombia
Oranjestad, Aruba
Willemstad, Curacao
Kralendijk, Bonaire
St. George's, Grenada...
View full list for ports of call
Sailing Dates:
November 17, 2025
interior from

Not Available

oceanview from

Not Available

balcony from

Not Available

suite from

$9,399

$587pernight
All the Cruise Line Offers & More:

Exclusive: Up to an Extra $4,000 savingsCall to book select 2025 and 2026 Regent Seven Seas voyages and save up to an extra $4,000. Savings is based upon length of cruise and as suite category booked. On voyages of 14-nights or less, Deluxe and Superior Suites save up to an extra $600 per suite, Concierge Suites save of up to an extra $800 per suite, and Penthouse Suites and above save up to an extra $1,100 per suite. On voyages of 15 to 29-nights, Deluxe and Superior save up to $1,000 per suite, Concierge save up to $1,300 per suite, and Penthouse Suites save up to $1,600 per suite. On voyages of 30-nights or longer, Deluxe and Superior save up to $2,000 per suite, Concierge save of up to $3,000 per suite, and Penthouse Suites and above save up to $4,000 per suite. Solo guests will receive half of these amounts. New bookings only. May not be combinable with all fares or promotions shown. Call for details before this offer ends at 11:59 PM EST on 08/31/2025.

Reduced Business-Class AirRegent Seven Seas Cruises is pleased to offer an incomparable inclusion that elevates their promise to deliver the most inclusive luxury experience: Reduced Business Class Air for all guests, for all suite categories on all Intercontinental flights. Arrive to your destination in complete comfort and style with Regent's Air-Inclusive Reduced Business Class Air program, including ground transfers between airport and ship, available from over 2 dozen popular US Gateways. Business-Class Air is subject to availability and may not be available on all sailings. All airline fees, surcharges and government fees, airline-imposed personal charges such as baggage fees may apply. Hurry - this offer will fly away soon. *35143

Unlimited Shore Excursions, Drinks, more

and more!
Suite from$9,399
($587pernight)

4.4 rating out of 5 (42 reviews)

View Itinerary View Itinerary Speak to an Expert
was $25,198

Up to 62% off
14 Night Exotic Coasts & Casco Viejo

Seven Seas Grandeur

4.3 rating out of 5 (10 reviews)
Departing from: Miami, Florida
Ports of Call

Sailing Dates

Bonus Offers
Ports of Call:
Costa Maya (Mahahual), Mexico
Harvest Caye, Belize
Roatan (Isla Roatan), Bay Islands, Honduras
George Town, Grand Cayman
Ocho Rios, Jamaica
Puerto Limon, Costa Rica
Cartagena, Colombia
Colon, Panama
Panama Canal Full Transit
Panama City, Panama
Sailing Dates:
February 23, 2027
interior from

Not Available

oceanview from

Not Available

balcony from

Not Available

suite from

$9,499

$679pernight
All the Cruise Line Offers & More:

Exclusive: Up to an Extra $2,000 savings
Call to book select 2027 Regent Seven Seas voyages and save an extra $2,000. Savings is based upon length of voyage as well as suite category booked. On voyages of 14-nights or less, Deluxe and Superior Suites save up to $300 per suite, Concierge Suites save up to $400 per suite, and Penthouse Suites and above save up to $550 per suite. On 15 to 29-nights, Deluxe and Superior save up to $500 per suite, Concierge save up to $650 per suite, and Penthouse and above save up to $800 per suite. On 30-nights or longer, Deluxe and Superior save up to $1,000 per suite, Concierge save up to $1,500 per suite, and Penthouse Suites and above save up to $2,000 per suite. Solo guests will receive half of these amounts. New bookings only. May not be combinable with all fares or promotions shown. Call for details before this offer ends at 11:59 PM EST on 08/31/2025.

Enjoy an Additional 5% SavingsFor a limited-time, you can enjoy an additional 5% savings off of your cruise fare in exchange for a non-refundable booking deposit. Your normal deposit payment schedule will still apply. If you choose to cancel the booking, your deposit amount will be non-refundable, but the remainder of the fare paid will follow Regent Seven Seas Cruises normal penalties and cancellation policy. This non-refundable deposit offer applies to any voyage of 60 nights or less, booked 180 days or more prior to the date of embarkation. This offer is for new bookings only and may not be combinable with all fares but is combinable with most promotions shown. Offer applies to all suite categories except for the Regent Suite. Availability of this offer is subject to availability and Regent Seven Seas Cruises reserves the right to remove sailings at any time without notice. Call today for more information. Hurry - this offer ends soon.

Reduced Business-Class AirRegent Seven Seas Cruises is pleased to offer an incomparable inclusion that elevates their promise to deliver the most inclusive luxury experience: Reduced Business Class Air for all guests, for all suite categories on all Intercontinental flights. Arrive to your destination in complete comfort and style with Regent's Air-Inclusive Reduced Business Class Air program, including ground transfers between airport and ship, available from over 2 dozen popular US Gateways. Business-Class Air is subject to availability and may not be available on all sailings. All airline fees, surcharges and government fees, airline-imposed personal charges such as baggage fees may apply. Hurry - this offer will fly away soon. *35143

Unlimited Shore Excursions, Drinks, more

and more!
Suite from$9,499
($679pernight)

4.3 rating out of 5 (10 reviews)

View Itinerary View Itinerary Speak to an Expert
was $26,998

Up to 63% off
16 Night Holiday in Panama

Seven Seas Splendor

4.4 rating out of 5 (42 reviews)
Departing from: Miami, Florida
Ports of Call

Sailing Dates

Bonus Offers
Ports of Call:
Ocho Rios, Jamaica
Cartagena, Colombia
Panama Canal Full Transit
Puntarenas, Costa Rica
Puerto Quetzal, Guatemala
Puerto Vallarta, Mexico
Cabo San Lucas, Mexico
San Pedro (Los Angeles), California
Sailing Dates:
December 20, 2027
interior from

Not Available

oceanview from

Not Available

balcony from

Not Available

suite from

$9,999

$625pernight
All the Cruise Line Offers & More:

Exclusive: Up to an Extra $2,000 savings
Call to book select 2027 Regent Seven Seas voyages and save an extra $2,000. Savings is based upon length of voyage as well as suite category booked. On voyages of 14-nights or less, Deluxe and Superior Suites save up to $300 per suite, Concierge Suites save up to $400 per suite, and Penthouse Suites and above save up to $550 per suite. On 15 to 29-nights, Deluxe and Superior save up to $500 per suite, Concierge save up to $650 per suite, and Penthouse and above save up to $800 per suite. On 30-nights or longer, Deluxe and Superior save up to $1,000 per suite, Concierge save up to $1,500 per suite, and Penthouse Suites and above save up to $2,000 per suite. Solo guests will receive half of these amounts. New bookings only. May not be combinable with all fares or promotions shown. Call for details before this offer ends at 11:59 PM EST on 08/31/2025.

Enjoy an Additional 5% SavingsFor a limited-time, you can enjoy an additional 5% savings off of your cruise fare in exchange for a non-refundable booking deposit. Your normal deposit payment schedule will still apply. If you choose to cancel the booking, your deposit amount will be non-refundable, but the remainder of the fare paid will follow Regent Seven Seas Cruises normal penalties and cancellation policy. This non-refundable deposit offer applies to any voyage of 60 nights or less, booked 180 days or more prior to the date of embarkation. This offer is for new bookings only and may not be combinable with all fares but is combinable with most promotions shown. Offer applies to all suite categories except for the Regent Suite. Availability of this offer is subject to availability and Regent Seven Seas Cruises reserves the right to remove sailings at any time without notice. Call today for more information. Hurry - this offer ends soon.

Reduced Business-Class AirRegent Seven Seas Cruises is pleased to offer an incomparable inclusion that elevates their promise to deliver the most inclusive luxury experience: Reduced Business Class Air for all guests, for all suite categories on all Intercontinental flights. Arrive to your destination in complete comfort and style with Regent's Air-Inclusive Reduced Business Class Air program, including ground transfers between airport and ship, available from over 2 dozen popular US Gateways. Business-Class Air is subject to availability and may not be available on all sailings. All airline fees, surcharges and government fees, airline-imposed personal charges such as baggage fees may apply. Hurry - this offer will fly away soon. *35143

and more!
Suite from$9,999
($625pernight)

4.4 rating out of 5 (42 reviews)

View Itinerary View Itinerary Speak to an Expert
was $26,998

Up to 63% off
14 Night Empires of the Sun

Seven Seas Voyager

4.0 rating out of 5 (103 reviews)
Departing from: Miami, Florida
Ports of Call

Sailing Dates
Ports of Call:
George Town, Grand Cayman
Falmouth, Jamaica
San Andres Island (Isla San Andres), Colombia
Puerto Limon, Costa Rica
Panama Canal Full Transit
Manta, Ecuador
Guayaquil, Equador
Salaverry (Trujillo), Peru
Callao (Lima), Peru
Sailing Dates:
January 13, 2028
interior from

Not Available

oceanview from

Not Available

balcony from

Not Available

suite from

$9,999

$714pernight

Suite from$9,999
($714pernight)

4.0 rating out of 5 (103 reviews)

View Itinerary View Itinerary Speak to an Expert
was $24,298

Up to 58% off
12 Night Majestic Beaches & Canal Crossing

Seven Seas Grandeur

4.3 rating out of 5 (10 reviews)
Departing from: Miami, Florida
Ports of Call

Sailing Dates

Bonus Offers
Ports of Call:
George Town, Grand Cayman
Ocho Rios, Jamaica
Kralendijk, Bonaire
Willemstad, Curacao
Oranjestad, Aruba
Cartagena, Colombia
Puerto Limon, Costa Rica
Panama Canal Full Transit
Panama City, Panama
Sailing Dates:
January 03, 2026
interior from

Not Available

oceanview from

Not Available

balcony from

Not Available

suite from

$10,149

$846pernight
All the Cruise Line Offers & More:

Exclusive: Up to an Extra $4,000 savingsCall to book select 2025 and 2026 Regent Seven Seas voyages and save up to an extra $4,000. Savings is based upon length of cruise and as suite category booked. On voyages of 14-nights or less, Deluxe and Superior Suites save up to an extra $600 per suite, Concierge Suites save of up to an extra $800 per suite, and Penthouse Suites and above save up to an extra $1,100 per suite. On voyages of 15 to 29-nights, Deluxe and Superior save up to $1,000 per suite, Concierge save up to $1,300 per suite, and Penthouse Suites save up to $1,600 per suite. On voyages of 30-nights or longer, Deluxe and Superior save up to $2,000 per suite, Concierge save of up to $3,000 per suite, and Penthouse Suites and above save up to $4,000 per suite. Solo guests will receive half of these amounts. New bookings only. May not be combinable with all fares or promotions shown. Call for details before this offer ends at 11:59 PM EST on 08/31/2025.

Reduced Business-Class AirRegent Seven Seas Cruises is pleased to offer an incomparable inclusion that elevates their promise to deliver the most inclusive luxury experience: Reduced Business Class Air for all guests, for all suite categories on all Intercontinental flights. Arrive to your destination in complete comfort and style with Regent's Air-Inclusive Reduced Business Class Air program, including ground transfers between airport and ship, available from over 2 dozen popular US Gateways. Business-Class Air is subject to availability and may not be available on all sailings. All airline fees, surcharges and government fees, airline-imposed personal charges such as baggage fees may apply. Hurry - this offer will fly away soon. *35143

Unlimited Shore Excursions, Drinks, more

and more!
Suite from$10,149
($846pernight)

4.3 rating out of 5 (10 reviews)

View Itinerary View Itinerary Speak to an Expert
was $26,998

Up to 61% off
15 Night Celestial Tropics

Seven Seas Prestige - New Ship!
Departing from: Miami, Florida
Ports of Call

Sailing Dates

Bonus Offers
Ports of Call:
George Town, Grand Cayman
Cartagena, Colombia
Panama Canal Full Transit
Puntarenas, Costa Rica
Puerto Quetzal, Guatemala
Cabo San Lucas, Mexico
Los Angeles, California
Sailing Dates:
January 20, 2027
interior from

Not Available

oceanview from

Not Available

balcony from

Not Available

suite from

$10,499

$700pernight
All the Cruise Line Offers & More:

Enjoy an Additional 5% SavingsFor a limited-time, you can enjoy an additional 5% savings off of your cruise fare in exchange for a non-refundable booking deposit. Your normal deposit payment schedule will still apply. If you choose to cancel the booking, your deposit amount will be non-refundable, but the remainder of the fare paid will follow Regent Seven Seas Cruises normal penalties and cancellation policy. This non-refundable deposit offer applies to any voyage of 60 nights or less, booked 180 days or more prior to the date of embarkation. This offer is for new bookings only and may not be combinable with all fares but is combinable with most promotions shown. Offer applies to all suite categories except for the Regent Suite. Availability of this offer is subject to availability and Regent Seven Seas Cruises reserves the right to remove sailings at any time without notice. Call today for more information. Hurry - this offer ends soon.

Unlimited Shore Excursions, Drinks, more
Suite from$10,499
($700pernight)

View Itinerary View Itinerary Speak to an Expert

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Cruise Search Results

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Filters Any

Your Selections:

Destination Any selected

Departure date filter Anyselected

Departure port Any selected

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Cruise ship Any selected

Special rates

We're sorry.

11 Night Crescent Beaches & Colorful Towns

Seven Seas Prestige - New Ship!

12 Night Bon Bin Aruba

Seven Seas Prestige - New Ship!

12 Night Flavors of Cartagena

Seven Seas Prestige - New Ship!

14 Night Carnival of Caribbean Colors

Seven Seas Grandeur

16 Night Southern Caribbean Beauty

Seven Seas Splendor

14 Night Exotic Coasts & Casco Viejo

Seven Seas Grandeur

16 Night Holiday in Panama

Seven Seas Splendor

14 Night Empires of the Sun

Seven Seas Voyager

12 Night Majestic Beaches & Canal Crossing

Seven Seas Grandeur

15 Night Celestial Tropics

Seven Seas Prestige - New Ship!

Cruise Search Results

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Special rates

We're sorry.

11 Night Crescent Beaches & Colorful Towns

Seven Seas Prestige - New Ship!

12 Night Bon Bin Aruba

Seven Seas Prestige - New Ship!

12 Night Flavors of Cartagena

Seven Seas Prestige - New Ship!

14 Night Carnival of Caribbean Colors

Seven Seas Grandeur

16 Night Southern Caribbean Beauty

Seven Seas Splendor

14 Night Exotic Coasts & Casco Viejo

Seven Seas Grandeur

16 Night Holiday in Panama

Seven Seas Splendor

14 Night Empires of the Sun

Seven Seas Voyager

12 Night Majestic Beaches & Canal Crossing

Seven Seas Grandeur

15 Night Celestial Tropics

Seven Seas Prestige - New Ship!

Filters Any

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Departure date filter Anyselected

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